Maraniol
Maraniol structure
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Common Name | Maraniol | ||
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| CAS Number | 87-05-8 | Molecular Weight | 204.222 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 351.4±37.0 °C at 760 mmHg | |
| Molecular Formula | C12H12O3 | Melting Point | 114-116 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 146.2±21.1 °C | |
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CYP2A6: genetics, structure, regulation, and function.
Drug Metabol. Drug Interact. 27 , 73-88, (2012) The human CYP2A gene subfamily consists of three members, CYP2A6, CYP2A7, and CYP2A13. The CYP2A6 gene is highly polymorphic with approximately 40 annotated allelic variants. Individuals homozygous for some of these alleles have a total lack of CYP2A6 activit... |
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Approach to detect substrates suitable to measure the coumarin 7-hydroxylase (Cyp 2a-5)-structure-activity relationships.
Arch. Pharm. (Weinheim) 327 , 299-302, (1994) Besides coumarin, which up to now has remained the most selective substrate for the coumarin 7-hydroxylase (Coh), 7-ethoxycoumarin, quinoline, 4-methylcoumarin, 7-ethoxy-4-methylcoumarin, 7-ethoxy-4-ethylcoumarin, and psoralen are suitable for this enzyme. Th... |
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7-Aminocoumarins are substrates of cytochrome P450-isozymes.
Arch. Pharm. (Weinheim) 331 , 143-148, (1998) N-Alkyl-7-aminocoumarins are dealkylated by murine cytochrome P450. There are differences between the N-dealkylation of secondary and tertiary amines. 7-Ethylamino-4-methylcoumarin is deethylated by isozymes induced by 3-methylcholanthrene, in contrast to 7-d... |
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Simultaneous determination of urinary metabolites of methoxypsoralens in human and Umbelliferae medicines by high-performance liquid chromatography.
J. Chromatogr. Sci. 44 , 473-478, (2006) A high-performance liquid chromatography method has been developed for the determination of coumarins and furocoumarins (psoralens). Nine coumarins and furocoumarins are separated simultaneously on a Hypersil C(8) (25 cm x 4.6-mm i.d.) column with a gradient ... |
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Non-animal photosafety screening for complex cosmetic ingredients with photochemical and photobiochemical assessment tools.
Regul Toxicol Pharmacol 72 , 578-85, (2015) Previously, a non-animal screening approach was proposed for evaluating photosafety of cosmetic ingredients by means of in vitro photochemical and photobiochemical assays; however, complex cosmetic ingredients, such as plant extracts and polymers, could not b... |
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[Determination of five coumarins in toys by high performance liquid chromatography-tandem mass spectrometry].
Se Pu 30(2) , 160-4, (2012) A rapid analytical method for the determination of five coumarins (coumarin, 7-methoxycoumarin, dihydrocoumarin, 7-methyl coumarin and 7-ethoxy-4-methyl coumarin) in toys by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) has been... |
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Induction of cytochrome P450 1A1 in rat liver slices by 7-ethoxycoumarin and 4-methyl-7-ethoxycoumarin.
Exp. Toxicol. Pathol. 50(4-6) , 491-6, (1998) 7-Ethoxycoumarin (EC) is widely used as a model substrate for monooxygenase function, its O-deethylation representing cytochrome P450 (P450) activity mainly of 1A but also of 2B isoforms. Reports on investigations of its own capacity to induce or suppress P45... |