ATIC-IN-1
Modify Date: 2024-02-08 20:19:30
ATIC-IN-1 structure
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Common Name | ATIC-IN-1 | ||
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| CAS Number | 1402453-15-9 | Molecular Weight | 463.53062 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H33N7O5 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ATIC-IN-1ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1]. |
| Name | L-Phenylalaninamide, N2-acetyl-L-arginyl-N,N-diethyl-4-nitro- |
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| Description | ATIC-IN-1(compound 14) is an inhibitor targeting to Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC) dimerization with a Ki value of 685 nM. ATIC dimerization is crucial for its aminoimidazole carboxamide ribonucleotide (AICAR) transformylase activity. ATIC-IN-1 exhibits anti-tumor activity via reduction in cell numbers and cell division rates[1]. |
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| Related Catalog | |
| Target |
Aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC)[1] |
| In Vitro | ATIC-IN-1（10 μM, 50 μM）是一种特异性抑制剂，在 1 mg/mL 和 10 mg/mL BSA 存在或不存在时，表现出非特异性聚集机制[1]。 ATIC-IN-1（100-500 μM；48 h）抑制 MCF-7 细胞的增殖[1]。 ATIC-IN-1（250 μM；24-72 小时）导致分裂减少而不是导致细胞死亡增加[1]。 Cell Viability Assay[1] Cell Line: MCF-7 cells Concentration: 100 μM, 250 μM, 500 μM Incubation Time: 0 h, 24 h, 48 h, and 72 h Result: Reduced the division rate to inhibit MCF-7 proliferation at 250 μM. |
| References |
| Molecular Formula | C21H33N7O5 |
|---|---|
| Molecular Weight | 463.53062 |