Cathepsin K inhibitor 3

Modify Date: 2024-07-20 12:36:33

Cathepsin K inhibitor 3 Structure
Cathepsin K inhibitor 3 structure
Common Name Cathepsin K inhibitor 3
CAS Number 1694638-70-4 Molecular Weight 562.65
Density N/A Boiling Point N/A
Molecular Formula C30H31FN4O4S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cathepsin K inhibitor 3


Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1].

 Names

Name Cathepsin K inhibitor 3

 Cathepsin K inhibitor 3 Biological Activity

Description Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1].
Related Catalog
Target

cathepsin K:0.5 nM (IC50)

In Vivo Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog[1]. The pharmacokinetic parameters of compound 23 Parameters Cl(mL/min/kg) T1/2(h) %F Rat 13 1 33 Dog 3.1 4.1 38 Rhesus 18.5 2.3 55

 Chemical & Physical Properties

Molecular Formula C30H31FN4O4S
Molecular Weight 562.65