KRAS inhibitor-12

Modify Date: 2024-01-13 17:50:53

KRAS inhibitor-12 structure	Common Name	KRAS inhibitor-12
	CAS Number	2230874-00-5	Molecular Weight	452.33
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₆Cl₂FN₅OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of KRAS inhibitor-12

KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].

Name	KRAS inhibitor-12

Description	KRAS inhibitor-12 (compound 6-1) is a potent KRAS G12C inhibitor with an IC50 of 0.537 µM. KRAS inhibitor-12 shows p-ERK inhibition activities with IC50s of 1.3, 3.7 µM in MIA PaCA-2, A549 cells, respectively. KRAS inhibitor-12 has the potential for the research of pancreatic, colorectal, and lung cancers[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Ras
Target	KRas G12C:0.537 μM (IC50)
References	[1]. Brian alan, et al. KRAS g12c inhibitors and methods of using the same. WO2018119183 A2

Molecular Formula	C₁₉H₁₆Cl₂FN₅OS
Molecular Weight	452.33

KRAS inhibitor-12

Use of KRAS inhibitor-12

Names

KRAS inhibitor-12 Biological Activity

Chemical & Physical Properties