COX-2/15-LOX-IN-1

Modify Date: 2024-09-04 09:11:43

COX-2/15-LOX-IN-1 Structure
COX-2/15-LOX-IN-1 structure
Common Name COX-2/15-LOX-IN-1
CAS Number 2413565-15-6 Molecular Weight 467.63
Density N/A Boiling Point N/A
Molecular Formula C21H21N7S3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of COX-2/15-LOX-IN-1


COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity[1].

 Names

Name COX-2/15-LOX-IN-1

 COX-2/15-LOX-IN-1 Biological Activity

Description COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity[1].
Related Catalog
Target

COX-1:10.65 μM (IC50)

COX-2:0.075 μM (IC50)

15-LOX:2.98 μM (IC50)

References

[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

 Chemical & Physical Properties

Molecular Formula C21H21N7S3
Molecular Weight 467.63