2413565-15-6

2413565-15-6 structure

Name: COX-2/15-LOX-IN-1
Chemical Name: COX-2/15-LOX-IN-1
CAS Number: 2413565-15-6
Molecular Formula: C₂₁H₂₁N₇S₃
Molecular Weight: 467.63
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-09-01 09:02:37
Modify Date: 2024-09-04 09:11:43
COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity[1].

Name	COX-2/15-LOX-IN-1

Description	COX-2/15-LOX-IN-1 (Compound 14) is a COX-2 and 15-lipoxygenase enzyme (15-LOX) inhibitor with IC50 values of 10.65, 0.075 and 2.98 μM against COX-1, COX-2 and 15-LOX, respectively. COX-2/15-LOX-IN-1 shows anti-inflammatory activity[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Target	COX-1:10.65 μM (IC50) COX-2:0.075 μM (IC50) 15-LOX:2.98 μM (IC50)
References	[1]. Maghraby MT, et al. Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes. Bioorg Med Chem. 2020 Apr 1;28(7):115403.

Molecular Formula	C₂₁H₂₁N₇S₃
Molecular Weight	467.63