2410384-50-6

2410384-50-6 structure

Name: COX-2/5-LOX-IN-1
Chemical Name: COX-2/5-LOX-IN-1
CAS Number: 2410384-50-6
Molecular Formula: C₁₄H₁₀ClN₃O₄S₂
Molecular Weight: 383.83
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2022-07-02 10:55:56
Modify Date: 2024-01-05 17:35:46
COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively[1].

Name	COX-2/5-LOX-IN-1

Description	COX-2/5-LOX-IN-1 (compound 3a) is a potent and dual inhibitor of COX-2/5-LOX. COX-2/5-LOX-IN-1 is a benzothiophen-2-yl pyrazole carboxylic acid derivative. COX-2/5-LOX-IN-1 shows the most potent analgesic and anti-inflammatory activities surpassing that of Celecoxib and Indomethacin. COX-2/5-LOX-IN-1 shows potent COX-1, COX-2 and 5-LOX inhibitory activity with IC50s of 12.13, 0.4 and 4.96 μM, respectively[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX
References	[1]. Gedawy EM, et al. Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors. Eur J Med Chem. 2020;189:112066.

Molecular Formula	C₁₄H₁₀ClN₃O₄S₂
Molecular Weight	383.83