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154355-75-6

154355-75-6 structure
154355-75-6 structure
  • Name: COX/5-LO-IN-1
  • Chemical Name: Atreleuton
  • CAS Number: 154355-75-6
  • Molecular Formula: C16H15FN2O2S
  • Molecular Weight: 318.371
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease 5-Lipoxygenase
  • Create Date: 2018-07-13 16:09:45
  • Modify Date: 2024-01-11 05:35:07
  • COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.

Name Atreleuton
Synonyms COX/5-LO-IN-1
Description COX/5-LO-IN-1 is an inhibitor of cylooxygenase and 5-lipoxygenase, used for the research of inflammatory and allergic disease states.
Related Catalog
Target

5-Lipoxygenase:2 μM (IC50)

COX

In Vitro COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states[1]. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC50 of 0.2 μM in human whole blood[2].
References

[1]. Lipoxygenase and cyclooxygenase inhibiting compounds. US 5516789 A

[2]. Brooks CD, et al. (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. J Med Chem. 1995 Nov 24;38(24):4768-75.

Molecular Formula C16H15FN2O2S
Molecular Weight 318.371