HDAC-IN-41

Modify Date: 2024-01-14 07:49:22

HDAC-IN-41 Structure
HDAC-IN-41 structure
Common Name HDAC-IN-41
CAS Number 2490309-83-4 Molecular Weight 446.48
Density N/A Boiling Point N/A
Molecular Formula C20H22N4O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of HDAC-IN-41


HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC50 values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity[1].

 Names

Name HDAC-IN-41

 HDAC-IN-41 Biological Activity

Description HDAC-IN-41 (Compound 7c) is a selective, orally active class I HDAC inhibitor with IC50 values of 0.62, 1.46 and 0.62 μM against HDAC1, HDAC2 and HDAC3, respectively. HDAC-IN-41 shows NO releasing activity[1].
Related Catalog
Target

HDAC1:0.62 μM (IC50)

HDAC2:1.46 μM (IC50)

HDAC3:0.62 μM (IC50)

In Vitro HDAC-IN-41 (Compound 7c) shows anti-proliferative activity with IC50 values of 0.32 ± 0.06, 0.59 ± 0.09, 0.54 ± 0.05, 1.23 ± 0.06, 2.69 ± 0.15, 0.93 ± 0.08 and 1.03 ± 0.09 μM against HEL, MOLT-4, Jurkat, HeLa, PC-3, HCT116 and A549 cells, respectively[1].
In Vivo HDAC-IN-41 (Compound 7c) (30 mg/kg/d; p.o., 15 days) inhibits tumor growth in a HCT116 xenograft model in nude mice[1].
References

[1]. Ding Q, et al. Synthesis and biological study of class I selective HDAC inhibitors with NO releasing activity. Bioorg Chem. 2020 Nov;104:104235.

 Chemical & Physical Properties

Molecular Formula C20H22N4O6S
Molecular Weight 446.48