hCAIX-IN-13

Modify Date: 2024-04-02 20:29:33

hCAIX-IN-13 Structure
hCAIX-IN-13 structure
Common Name hCAIX-IN-13
CAS Number 2813334-66-4 Molecular Weight 989.90
Density N/A Boiling Point N/A
Molecular Formula C37H33F3N6O7PtS2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of hCAIX-IN-13


hCAIX-IN-13 (Pt2) is an inhibitor of CAIX (arbonic anhydrase IX) with an IC50 value of 6.57 μM. hCAIX-IN-13 inhibits growth of cancer cells and induces cell apoptosis, it can be used for the research of cancer[1].

 Names

Name hCAIX-IN-13

 hCAIX-IN-13 Biological Activity

Description hCAIX-IN-13 (Pt2) is an inhibitor of CAIX (arbonic anhydrase IX) with an IC50 value of 6.57 μM. hCAIX-IN-13 inhibits growth of cancer cells and induces cell apoptosis, it can be used for the research of cancer[1].
Related Catalog
Target

IC50: 6.57 μM (CAIX)[1]

In Vitro hCAIX-IN-13 (10 and 20 μM; 24 h) effectively attenuates extracellular acidification through the inhibited activity of the cellular CAIX expression[1]. hCAIX-IN-13 (20 and 40 μM; 24 h) affects CAIX expression[1]. hCAIX-IN-13 (0-200 μM; 24 h) shows high cytotoxicity to cancer cell lines[1]. hCAIX-IN-13 (5-15 μM; 24 h) promotes the production of cellular ROS[1]. hCAIX-IN-13 (5-20 μM; 48 h) induces cell apoptosis[1]. Western Blot Analysis[1] Cell Line: MDA-MB-231 cell line Concentration: 20 and 40 μM Incubation Time: 24 hours Result: Dose-dependently inhibited the expression level of cellular CAIX. Cell Cytotoxicity Assay[1] Cell Line: Hela, A549, MDA-MB 231, HLF and LO2 cell lines Concentration: 0-200 μM Incubation Time: 48 hours Result: Showed cytotoxicity to Hela, A549, MDA-MB 231, normal cell HLF and normal cell LO2 with IC50s of 31.64, 30.45, 12.67, 21.64 and >100 μM, respectively. Apoptosis Analysis[1] Cell Line: MDA-MB-231 cell line Concentration: 5-20 μM Incubation Time: 48 hours Result: Dose-dependently induced the early apoptotic stage.
References

[1]. Yang J, et al. NIR phosphorescent cyclometalated platinum (II) complexes with CAIX targeted and nuclear penetration as potent anticancer theragnostic agents. Eur J Med Chem. 2022 Aug 31;243:114702.

 Chemical & Physical Properties

Molecular Formula C37H33F3N6O7PtS2
Molecular Weight 989.90