Name | (2S,4R)-4-[[2-[(1R,3R)-1-acetyloxy-4-methyl-3-[3-methylbutanoyloxymethyl-[(2S,3S)-3-methyl-2-[[(2R)-1-methylpiperidine-2-carbonyl]amino]pentanoyl]amino]pentyl]-1,3-thiazole-4-carbonyl]amino]-5-(4-hydroxyphenyl)-2-methylpentanoic acid |
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Synonyms |
TubA
Tubulysin A |
Description | Tubulysin A(TubA) is a myxobacterial product that can function as an antiangiogenic agent in many in vitro assays; anti-microtubule, anti-mitotic, an apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative.IC50 value: Target: microtubuleTubulysin A is a novel antibiotic, which is anti-microtubule, anti-mitotic, apoptosis inducer, anticancer, anti-angiogenic, and antiproliferative. Tubulysins are cytotoxic peptides, which include 9 members (A-I). Tubulysin A has potential application as an anticancer agent. It arrests cells in the G2/M phase. Tubulysin A inhibits polymerization more efficiently than vinblastine and induces depolymerization of isolated microtubules. Tubulysin A has potent cytostatic effects on various tumor cell lines with IC50 in the picomolar range. |
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Related Catalog | |
References |
Molecular Formula | C43H65N5O10S |
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Molecular Weight | 844.06900 |
Exact Mass | 843.44500 |
PSA | 239.99000 |
LogP | 7.06310 |
Appearance | colorless or white |
Storage condition | 2-8°C |
Water Solubility | organic solvents: soluble |
Symbol |
GHS06 |
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Signal Word | Danger |
Hazard Statements | H301-H311-H315-H319-H331-H335 |
Precautionary Statements | P261-P280-P301 + P310-P305 + P351 + P338-P311 |
Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
Hazard Codes | T |
Risk Phrases | 23/24/25-36/37/38 |
Safety Phrases | 36/37-45 |
RIDADR | UN 2811 6.1 / PGIII |