1245823-51-1

1245823-51-1 structure

Name: Propargyl-PEG4-C2-acid
Chemical Name: Acetylene-PEG5-acid
CAS Number: 1245823-51-1
Molecular Formula: C₁₄H₂₄O₇
Molecular Weight: 304.33600
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2017-04-27 01:52:24
Modify Date: 2024-01-13 11:49:28
Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3[1].

Name	Acetylene-PEG5-acid
Synonyms	3-(2-{2-[2-(2-prop-2-ynyloxyethoxy)ethoxy]ethoxy}ethoxy)propanoic acid Alkyne-PEG5-acid PROPARGYL-PEG5-ACID

Description	Propargyl-PEG5-acid is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG5-acid can used to synthesize ADC inhibitors of Galectin-3[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Non-cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Zhang H, et al. Thiodigalactoside-Bovine Serum Albumin Conjugates as High-Potency Inhibitors of Galectin-3: An Outstanding Example of Multivalent Presentation of Small Molecule Inhibitors. Bioconjug Chem. 2018 Apr 18;29(4):1266-1275.

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
RIDADR	NONH for all modes of transport