1415800-32-6
1415800-32-6 structure
- Name: Propargyl-PEG4-acid
- Chemical Name: 4,7,10,13-Tetraoxahexadec-15-yn-1-oic acid
- CAS Number: 1415800-32-6
- Molecular Formula: C12H20O6
- Molecular Weight: 260.284
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2018-06-10 08:02:35
- Modify Date: 2024-01-17 08:33:43
-
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1].
| Name | 4,7,10,13-Tetraoxahexadec-15-yn-1-oic acid |
|---|---|
| Synonyms |
MFCD22683284
4,7,10,13-Tetraoxahexadec-15-yn-1-oic acid Propargyl-PEG4-acid |
| Description | Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib (HY-10997)-based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | BTK-IAP PROTACs act as stoichiometric degraders, resulting in degradation of BTK protein. Degradation of BTK is a result of IAP E3 ligases family recruitment[1]. |
| References |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 388.0±37.0 °C at 760 mmHg |
| Molecular Formula | C12H20O6 |
| Molecular Weight | 260.284 |
| Flash Point | 141.0±20.0 °C |
| Exact Mass | 260.125977 |
| LogP | -0.80 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.468 |
| Hazard Codes | Xi |
|---|