1225497-78-8

1225497-78-8 structure

Name: ON-01910
Chemical Name: Rigosertib
CAS Number: 1225497-78-8
Molecular Formula: C₂₁H₂₄NNaO₈S
Molecular Weight: 473.47
Catalog: Biochemical Amino acids and their derivatives Glycine derivatives
Create Date: 2018-11-26 18:01:35
Modify Date: 2024-01-04 12:49:05
Rigosertib (ON-01910) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Name	Rigosertib
Synonyms	Glycine, N-[2-methoxy-5-[[[2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]phenyl]-, sodium salt (1:1) Sodium {[2-methoxy-5-({[2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methyl)phenyl]amino}acetate ON-01910 Estybon Sodium {[2-methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfo nyl}methyl)phenyl]amino}acetate

Description	Rigosertib (ON-01910) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK)
Target	PLK1
In Vitro	Rigosertib (ON-01910) sodium 是一种非 ATP 竞争性 PLK1 抑制剂，IC50 为 9 nM，比 Plk2 选择性高 30 倍，对 Plk3 没有抑制活性。
References	[1]. Gumireddy K, et al. ON01910, a non-ATP-competitive small molecule inhibitor of Plk1, is a potent anticancer agent. Cancer Cell. 2005 Mar;7(3):275-86.