- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: SIA Crosslinker
- Price: Check
- Purity: 95.0%
- Stocking Period: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: SIA Crosslinker
- Price: ￥648.0/25mg ￥1818.0/100mg
- Purity: 95.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: SIA Crosslinker
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: N-SUCCINIMIDYL IODOACETATE
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
39028-27-8
39028-27-8 structure
- Name: SIA Crosslinker
- Chemical Name: iodoacetic acid n-hydroxysuccinimide ester
- CAS Number: 39028-27-8
- Molecular Formula: C6H6INO4
- Molecular Weight: 283.021
- Catalog: Chemical reagent Organic reagent Imide
- Create Date: 2018-03-03 08:00:00
- Modify Date: 2024-01-02 18:11:47
-
SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
| Name | iodoacetic acid n-hydroxysuccinimide ester |
|---|---|
| Synonyms |
1-(2-Iodoacetoxy)-2,5-pyrrolidinedione
N-SucciniMidyl Iodoacetate 2,5-Pyrrolidinedione, 1-[(2-iodoacetyl)oxy]- N-(Iodoacetoxy)succinimide 1-(2-Iodoacetoxy)pyrrolidine-2,5-dione Iodoacetic Acid N-Succinimidyl Ester (2,5-dioxopyrrolidin-1-yl) 2-iodoacetate N-Succinimidyl iodoacetate(SIA) |
| Description | SIA Crosslinker is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. |
|---|---|
| Related Catalog | |
| Target |
Non-cleavable |
| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. |
| References |
| Density | 2.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 315.6±44.0 °C at 760 mmHg |
| Melting Point | 148ºC |
| Molecular Formula | C6H6INO4 |
| Molecular Weight | 283.021 |
| Flash Point | 144.7±28.4 °C |
| Exact Mass | 282.934143 |
| PSA | 63.68000 |
| LogP | -0.76 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.615 |
| Storage condition | −20°C |
| Water Solubility | DMF: 50 mg/mL |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2925190090 |
|
~29%
39028-27-8 |
| Literature: Marco Colas, Maria Pilar; Sánchez Baeza, Francisco José; González Pinacho, Daniel Patent: US2013/273581 A1, 2013 ; Location in patent: Page/Page column 0092; 0111-0112; 0114 ; |
| HS Code | 2925190090 |
|---|---|
| Summary | 2925190090 other imides and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |