BioBioPha
China
Product Name: 5-Heptadecyl-1,3-benzenediol
Price: ￥3000.0/5mg
Purity: 98.0%
Stocking Period: 10 Day
Contact: Xueping-Zheng

41442-57-3

41442-57-3 structure

Name: 5-Heptadecyl-1,3-benzenediol
Chemical Name: 5-heptadecylbenzene-1,3-diol
CAS Number: 41442-57-3
Molecular Formula: C₂₃H₄₀O₂
Molecular Weight: 348.56
Catalog: Natural product Phenols
Create Date: 2018-04-14 08:00:00
Modify Date: 2024-01-10 19:57:15
5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity[1][2].

Name	5-heptadecylbenzene-1,3-diol
Synonyms	5-Heptadecyl-1,3-dihydroxybenzene 5-Heptadecyl-1,3-benzenediol 5-N-Heptadecylresorcinol 1,3-DIHYDROXY-5-HEPTADECYLBENZEN 1,3-Benzenediol, 5-heptadecyl- 5-heptadecylbenzene-1,3-diol 5-Heptadecylresorcinol

Description	5-Heptadecylresorcinol (AR-C17), a phenolic lipid component, is also an orally active mitochondrial protector. 5-Heptadecylresorcinol improves mitochondrial function via sirtuin3 signaling pathway, thus alleviates endothelial cell damage and apoptosis. 5-Heptadecylresorcinol induces sirtuin3-mediated autophagy. 5-Heptadecylresorcinol reduces the atherosclerotic plaques in the aortic root region of mice heart. 5-Heptadecylresorcinol can be used for research of atherosclerosis prevention and obesity[1][2].
Related Catalog	Signaling Pathways >> Epigenetics >> Sirtuin Research Areas >> Cardiovascular Disease Signaling Pathways >> Cell Cycle/DNA Damage >> Sirtuin Research Areas >> Metabolic Disease
Target	SIRT3
In Vitro	5-Heptadecylresorcinol（0、0.5、1 和 2 µM；24 小时）通过上调 HUVEC 中的 SIRT3 减轻线粒体功能障碍[1]。 5-Heptadecylresorcinol 减轻了炎症条件培养基 (CM) 诱导的脂肪细胞脂肪分解和线粒体损伤，同时减弱了线粒体活性氧的产生和线粒体膜去极化[2]。 5-Heptadecylresorcinol（5、10 和 15 μM；24 小时）通过减少 3T3-L1 脂肪细胞中甘油的释放显着防止 CM 诱导的脂肪细胞脂肪分解[2]。 5-Heptadecylresorcinol（5、10 和 15 μM；24 小时）改善 CM 诱导的脂肪细胞线粒体功能障碍[2]。 Western Blot Analysis[2] Cell Line: 3T3-L1 adipocytes Concentration: 5, 10 and 15 μM Incubation Time: 24 hours Result: Increased the expression of UCP1, COX IV, PGC-1α, DRP1 and MFN2 proteins.
In Vivo	5-Heptadecylresorcinol（30 mg/kg、150 mg/kg；每日口服，持续 16 周）改善高脂饮食喂养的 ApoE−/− 小鼠的脂质代谢[1]。 5-Heptadecylresorcinol（30 mg/kg、150 mg/kg；每天口服，持续 16 周）增加小鼠体重，减轻脂肪组织巨噬细胞浸润和线粒体功能障碍[2]。 Animal Model: C57BL/6J mice[1][2] Dosage: 30 mg/kg, 150 mg/kg Administration: PO; daily for 16 weeks Result: Lowered serum total cholesterol, triglyceride, VLDL-C, and LDL-C levels[1]. Reduced adipose tissue macrophage infiltration from high-fat diet induced obese C57BL/6J mice[2].
References	[1]. Rakshit D, et al. The Pharmacological Activity of Garlic (Allium sativum) in Parkinson's Disease: From Molecular Mechanisms to the Therapeutic Potential. ACS Chem Neurosci. 2023 Mar 15;14(6):1033-1044. [2]. Yoo DY, et al. Neuroprotective effects of Z-ajoene, an organosulfur compound derived from oil-macerated garlic, in the gerbil hippocampal CA1 region after transient forebrain ischemia. Food Chem Toxicol. 2014 Oct;72:1-7.

Density	1.0±0.1 g/cm3
Boiling Point	478.0±15.0 °C at 760 mmHg
Molecular Formula	C₂₃H₄₀O₂
Molecular Weight	348.56
Flash Point	202.6±15.0 °C
Exact Mass	348.302826
PSA	40.46000
LogP	9.72
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.507
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H319
Precautionary Statements	P305 + P351 + P338
Hazard Codes	Xi
Risk Phrases	36
Safety Phrases	26
RIDADR	NONH for all modes of transport
HS Code	2907299090

41395-17-9

~94%

41442-57-3

Literature: Zhu, Yingdong; Soroka, Dominique N.; Sang, Shengmin Journal of Agricultural and Food Chemistry, 2012 , vol. 60, # 35 p. 8624 - 8631

1190372-76-9

~77%

41442-57-3

Literature: Wu, Li-Qiang; Yang, Chun-Guang; Yang, Li-Ming; Yang, Li-Juan Journal of Chemical Research, 2009 , # 3 p. 183 - 185

52483-25-7

41442-57-3

Literature: Arisawa; Ohmura; Kobayashi; Morita Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2431 - 2434

872-26-4

41442-57-3

Literature: Arisawa; Ohmura; Kobayashi; Morita Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2431 - 2434

17213-57-9

41442-57-3

Literature: Arisawa; Ohmura; Kobayashi; Morita Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2431 - 2434

Precursor 3
41395-17-9 872-26-4 17213-57-9
DownStream 0

HS Code	2907299090
Summary	2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

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