4981-83-3

4981-83-3 structure

Name: Benzyl-PEG1-Tos
Chemical Name: 2-(benzyloxy)ethyl 4-methylbenzenesulfonate (en)Ethanol, 2-(phenylmethoxy)-, 4-methylbenzenesulfonate (en)
CAS Number: 4981-83-3
Molecular Formula: C₁₆H₁₈O₄S
Molecular Weight: 306.37700
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-04-23 09:10:14
Modify Date: 2024-01-09 16:11:23
Benzyl-PEG1-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(benzyloxy)ethyl 4-methylbenzenesulfonate (en)Ethanol, 2-(phenylmethoxy)-, 4-methylbenzenesulfonate (en)
Synonyms	1-benzyloxy-2-tosyloxyethane 2-benzyloxyethyl p-toluenesulfonate 2-Benzyl-Oxyethyl Chloroformate 1-O-benzyl-2-O-p-toluenesulfonyl ethylene glycol

Description	Benzyl-PEG1-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562