58841-52-4
58841-52-4 structure
- Name: Benzyl-PEG1-Ms
- Chemical Name: methanesulfonic acid,2-phenylmethoxyethanol
- CAS Number: 58841-52-4
- Molecular Formula: C10H16O5S
- Molecular Weight: 248.29600
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2017-08-09 11:25:18
- Modify Date: 2024-01-10 13:12:18
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Benzyl-PEG1-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
| Name | methanesulfonic acid,2-phenylmethoxyethanol |
|---|---|
| Synonyms |
2-benzyloxyethyl mesylate
benzyl 2-methylsulphonyloxyethyl ether 2-(benzyloxy)ethyl methanesulfonate 2-benzyloxy-1-(methanesulfonyloxy)ethane 2-(phenylmethoxy)ethanol methanesulphonate Ethanol,2-(phenylmethoxy)-,methanesulfonate methanesulfonic acid 2-benzyloxyethyl ester |
| Description | Benzyl-PEG1-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. |
| References |
| Density | 1.218g/cm3 |
|---|---|
| Boiling Point | 375.438ºC at 760 mmHg |
| Molecular Formula | C10H16O5S |
| Molecular Weight | 248.29600 |
| Flash Point | 180.858ºC |
| Exact Mass | 248.07200 |
| PSA | 92.21000 |
| LogP | 1.78030 |
| Index of Refraction | 1.521 |
|
~99%
58841-52-4 |
| Literature: Mahboobi, Siavosh; Bernauer, Karl Helvetica Chimica Acta, 1988 , vol. 71, p. 2034 - 2041 |
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58841-52-4 |
| Literature: Sumitomo Chemical Company, Limited Patent: US2005/256322 A1, 2005 ; |
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58841-52-4 |
| Literature: Schomaker, Jennifer M.; Bhattacharjee, Somnath; Yan, Jun; Borhan, Babak Journal of the American Chemical Society, 2007 , vol. 129, # 7 p. 1996 - 2003 |
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58841-52-4 |
| Literature: Farr; Bey; Sunkara; Lippert Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1879 - 1885 |
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58841-52-4 |
| Literature: Farr; Bey; Sunkara; Lippert Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1879 - 1885 |
|
~%
58841-52-4 |
| Literature: Farr; Bey; Sunkara; Lippert Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1879 - 1885 |
|
~%
58841-52-4 |
| Literature: Mahboobi, Siavosh; Bernauer, Karl Helvetica Chimica Acta, 1988 , vol. 71, p. 2034 - 2041 |
