Benzyl-PEG1-Ms

Modify Date: 2024-01-10 13:12:18

Benzyl-PEG1-Ms Structure
Benzyl-PEG1-Ms structure
Common Name Benzyl-PEG1-Ms
CAS Number 58841-52-4 Molecular Weight 248.29600
Density 1.218g/cm3 Boiling Point 375.438ºC at 760 mmHg
Molecular Formula C10H16O5S Melting Point N/A
MSDS N/A Flash Point 180.858ºC

 Use of Benzyl-PEG1-Ms


Benzyl-PEG1-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name methanesulfonic acid,2-phenylmethoxyethanol
Synonym More Synonyms

 Benzyl-PEG1-Ms Biological Activity

Description Benzyl-PEG1-Ms is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.218g/cm3
Boiling Point 375.438ºC at 760 mmHg
Molecular Formula C10H16O5S
Molecular Weight 248.29600
Flash Point 180.858ºC
Exact Mass 248.07200
PSA 92.21000
LogP 1.78030
Index of Refraction 1.521

 Synthetic Route

~99%

Benzyl-PEG1-Ms Structure

Benzyl-PEG1-Ms

CAS#:58841-52-4

Literature: Mahboobi, Siavosh; Bernauer, Karl Helvetica Chimica Acta, 1988 , vol. 71, p. 2034 - 2041

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Benzyl-PEG1-Ms Structure

Benzyl-PEG1-Ms

CAS#:58841-52-4

Literature: Sumitomo Chemical Company, Limited Patent: US2005/256322 A1, 2005 ;

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Benzyl-PEG1-Ms Structure

Benzyl-PEG1-Ms

CAS#:58841-52-4

Literature: Schomaker, Jennifer M.; Bhattacharjee, Somnath; Yan, Jun; Borhan, Babak Journal of the American Chemical Society, 2007 , vol. 129, # 7 p. 1996 - 2003

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Benzyl-PEG1-Ms Structure

Benzyl-PEG1-Ms

CAS#:58841-52-4

Literature: Farr; Bey; Sunkara; Lippert Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1879 - 1885

~%

Benzyl-PEG1-Ms Structure

Benzyl-PEG1-Ms

CAS#:58841-52-4

Literature: Farr; Bey; Sunkara; Lippert Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1879 - 1885

~%

Benzyl-PEG1-Ms Structure

Benzyl-PEG1-Ms

CAS#:58841-52-4

Literature: Farr; Bey; Sunkara; Lippert Journal of Medicinal Chemistry, 1989 , vol. 32, # 8 p. 1879 - 1885

~%

Benzyl-PEG1-Ms Structure

Benzyl-PEG1-Ms

CAS#:58841-52-4

Literature: Mahboobi, Siavosh; Bernauer, Karl Helvetica Chimica Acta, 1988 , vol. 71, p. 2034 - 2041

 Synonyms

2-benzyloxyethyl mesylate
benzyl 2-methylsulphonyloxyethyl ether
2-(benzyloxy)ethyl methanesulfonate
2-benzyloxy-1-(methanesulfonyloxy)ethane
2-(phenylmethoxy)ethanol methanesulphonate
Ethanol,2-(phenylmethoxy)-,methanesulfonate
methanesulfonic acid 2-benzyloxyethyl ester
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