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98627-22-6

98627-22-6 structure
98627-22-6 structure
  • Name: Benzyl-PEG2-Tos
  • Chemical Name: 2-[2-(Benzyloxy)ethoxy]ethyl 4-methylbenzenesulfonate
  • CAS Number: 98627-22-6
  • Molecular Formula: C18H22O5S
  • Molecular Weight: 350.429
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2018-07-15 11:05:43
  • Modify Date: 2024-01-10 17:44:17
  • Benzyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-[2-(Benzyloxy)ethoxy]ethyl 4-methylbenzenesulfonate
Synonyms 2-[2-(Benzyloxy)ethoxy]ethyl 4-methylbenzenesulfonate
Ethanol, 2-[2-(phenylmethoxy)ethoxy]-, 4-methylbenzenesulfonate
MFCD28064331
Description Benzyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Density 1.2±0.1 g/cm3
Boiling Point 487.4±35.0 °C at 760 mmHg
Molecular Formula C18H22O5S
Molecular Weight 350.429
Flash Point 248.6±25.9 °C
Exact Mass 350.118805
LogP 3.00
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.549