82034-46-6
82034-46-6 structure
- Name: Loteprednol etabonate
- Chemical Name: loteprednol etabonate
- CAS Number: 82034-46-6
- Molecular Formula: C24H31ClO7
- Molecular Weight: 466.952
- Catalog: Biochemical Inhibitor Endocrinology & Hormones Glucocorticoid Receptor Agonist
- Create Date: 2018-09-18 16:02:48
- Modify Date: 2024-01-02 19:28:32
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Loteprednol Etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.IC50 Value:Target: Glucocorticoid Receptorin vitro:in vivo: Intravenous administration of loteprednol etabonate (5 mg/kg) to dogs revealed a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect. A pronounced binding of the drug to plasma protein (> 90%) and a high erythrocyte-buffer partition coefficient of 7.8 were determined in vitro.
| Name | loteprednol etabonate |
|---|---|
| Synonyms |
Androsta-1,4-diene-17-carboxylic acid, 17-((ethoxycarbonyl)oxy)-11-hydroxy-3-oxo-, chloromethyl ester, (11β,17α)-
chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylate (8S,9S,10R,11S,13S,14S,17R)-17-[(éthoxycarbonyl)oxy]-11-hydroxy-10,13-diméthyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodécahydro-3H-cyclopenta[a]phénanthrène-17-carboxylate de chlorométhyle Chloromethyl 17a-ethoxycarbonyloxy-11b-hydroxyandrosta-1,4-diene-3-one-17b-carboxylate (11b,17a)-17-[(Ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylic Acid Chloromethyl Ester Loteprednol (INN) Androsta-1,4-diene-17-carboxylic acid, 17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxo-, chloromethyl ester, (11β,17α)- Loteprednolum Loteprednol Etabonate 17a-Ethoxycarbonyloxy-D'-cortienic Acid Chloromethyl Ester Loteprednol [INN:BAN] Chloromethyl (11β,17α)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate HGP 1 loteprednol Chlormethyl-(8S,9S,10R,11S,13S,14S,17R)-17-[(ethoxycarbonyl)oxy]-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-carboxylat |
| Description | Loteprednol Etabonate is an anti-inflammatory corticosteroid used in optometry and ophthalmology.IC50 Value:Target: Glucocorticoid Receptorin vitro:in vivo: Intravenous administration of loteprednol etabonate (5 mg/kg) to dogs revealed a terminal half-life of 2.8 h, a volume of distribution of 3.7 L/kg, and a total body clearance of 0.9 L/h/kg. Intact loteprednol etabonate was not detectable in the urine. After oral administration of the drug (5 mg/kg) to dogs, only metabolites, but no intact drug, were found in the plasma, an indication for a high first-pass effect. A pronounced binding of the drug to plasma protein (> 90%) and a high erythrocyte-buffer partition coefficient of 7.8 were determined in vitro. |
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| Related Catalog | |
| References |
[6]. Loteprednol |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 600.1±55.0 °C at 760 mmHg |
| Melting Point | 220.5-223.5ºC |
| Molecular Formula | C24H31ClO7 |
| Molecular Weight | 466.952 |
| Flash Point | 316.7±31.5 °C |
| Exact Mass | 466.175842 |
| PSA | 99.13000 |
| LogP | 3.17 |
| Appearance | white to beige |
| Vapour Pressure | 0.0±3.9 mmHg at 25°C |
| Index of Refraction | 1.571 |
| Storage condition | -20°C Freezer |
| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
| Hazard Codes | Xi |
|---|---|
| RIDADR | NONH for all modes of transport |
| HS Code | 2937229000 |
| HS Code | 2937229000 |
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