623152-17-0
623152-17-0 structure
- Name: BMS-582949
- Chemical Name: 4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
- CAS Number: 623152-17-0
- Molecular Formula: C22H26N6O2
- Molecular Weight: 406.48
- Catalog: Signaling Pathways MAPK/ERK Pathway p38 MAPK
- Create Date: 2016-03-09 03:58:06
- Modify Date: 2024-01-11 10:15:24
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BMS-582949 (compound 7k) is an orally active and highly selective p38α MAP kinase inhibitor, with IC50 values of 13 nM for p38α, and 50 nM for cellular TNFα. BMS-582949 can be used for research on rheumatoid arthritis[1].
| Name | 4-[5-(cyclopropylcarbamoyl)-2-methylanilino]-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide |
|---|---|
| Synonyms |
38P
3mvl UNII-CR743OME9E BMS-582949 BMS-582949 HCl |
| Description | BMS-582949 (compound 7k) is an orally active and highly selective p38α MAP kinase inhibitor, with IC50 values of 13 nM for p38α, and 50 nM for cellular TNFα. BMS-582949 can be used for research on rheumatoid arthritis[1]. |
|---|---|
| Related Catalog | |
| Target |
p38α:13 nM (IC50) |
| References |
| Molecular Formula | C22H26N6O2 |
|---|---|
| Molecular Weight | 406.48 |
| Exact Mass | 406.21200 |
| PSA | 110.63000 |
| LogP | 3.69320 |
| Storage condition | -20℃ |
|
~94%
623152-17-0 |
| Literature: Kim, Soojin; Malley, Mary F.; Shi, Zhongping Patent: US2006/235020 A1, 2006 ; Location in patent: Page/Page column 22-23 ; |
|
~88%
623152-17-0 |
| Literature: Cann, Reginald O.; Delaney, Edward J.; Fan, Junying; Parlanti, Luca Patent: US2006/35886 A1, 2006 ; Location in patent: Page/Page column 13 ; US 20060035886 A1 |
| Precursor 2 | |
|---|---|
| DownStream 0 | |