26150-06-1

26150-06-1 structure

Name: Acryloyl-PEG4-OH
Chemical Name: 2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethanol
CAS Number: 26150-06-1
Molecular Formula: C₁₁H₂₂O₅
Molecular Weight: 234.28900
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2016-10-02 22:38:54
Modify Date: 2024-01-03 16:47:21
Acryloyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethanol
Synonyms	2-(2-(2-(2-allyloxy-ethoxy)-ethoxy)-ethoxy)-ethanol 2-(2-(2-(2-allyloxyethoxy)ethoxy)ethoxy)ethan-1-ol 2-{2-[2-(-allyloxyethoxy)ethoxy]ethoxy}ethanol 3,6,9,12-Tetraoxapentadec-14-en-1-ol tetraethylene glycol allyl ether tetraethylene glycol monoallyl ether

Description	Acryloyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula	C₁₁H₂₂O₅
Molecular Weight	234.28900
Exact Mass	234.14700
PSA	57.15000
LogP	0.23110

112-60-7

106-95-6

~74%

26150-06-1

Literature: Xu, William Z.; Zhang, Xinyue; Kadla, John F. Biomacromolecules, 2012 , vol. 13, # 2 p. 350 - 357

112-60-7

26150-06-1

Literature: ISIS INNOVATION LIMITED Patent: US2012/178913 A1, 2012 ;

112-60-7

107-05-1

~24%

58185-54-9

26150-06-1

Literature: Petersen, Svea; Alonso, Jose Maria; Specht, Alexandre; Duodu, Portia; Goeldner, Maurice; Del Campo, Aranzazu Angewandte Chemie - International Edition, 2008 , vol. 47, # 17 p. 3192 - 3195

112-60-7

106-95-6

~50%

58185-54-9

26150-06-1

Literature: Breed; Ramsden; Brown Canadian Journal of Chemistry, 2001 , vol. 79, # 5-6 p. 1049 - 1057

112-60-7

107-05-1

~39%

26150-06-1

Literature: Ali-Adib, Ziad; Bomben, Andrea; Davis, Frank; Hodge, Philip; Tundo, Pietro; Valli, Ludovico Journal of Materials Chemistry, 1996 , vol. 6, # 1 art. no. 5/02127H, p. 15 - 22

106-95-6

26150-06-1

Literature: Riemschneider; Koetzsch Monatshefte fuer Chemie, 1959 , vol. 90, p. 787,788,790

Precursor 3
112-60-7 106-95-6 107-05-1
DownStream 3
352439-36-2 6790-09-6 98269-27-3

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