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26150-06-1

26150-06-1 structure
26150-06-1 structure
  • Name: Acryloyl-PEG4-OH
  • Chemical Name: 2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethanol
  • CAS Number: 26150-06-1
  • Molecular Formula: C11H22O5
  • Molecular Weight: 234.28900
  • Catalog: Signaling Pathways PROTAC PROTAC Linker
  • Create Date: 2016-10-02 22:38:54
  • Modify Date: 2024-01-03 16:47:21
  • Acryloyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name 2-[2-[2-(2-prop-2-enoxyethoxy)ethoxy]ethoxy]ethanol
Synonyms 2-(2-(2-(2-allyloxy-ethoxy)-ethoxy)-ethoxy)-ethanol
2-(2-(2-(2-allyloxyethoxy)ethoxy)ethoxy)ethan-1-ol
2-{2-[2-(-allyloxyethoxy)ethoxy]ethoxy}ethanol
3,6,9,12-Tetraoxapentadec-14-en-1-ol
tetraethylene glycol allyl ether
tetraethylene glycol monoallyl ether
Description Acryloyl-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Molecular Formula C11H22O5
Molecular Weight 234.28900
Exact Mass 234.14700
PSA 57.15000
LogP 0.23110

~74%

26150-06-1 structure

26150-06-1

Literature: Xu, William Z.; Zhang, Xinyue; Kadla, John F. Biomacromolecules, 2012 , vol. 13, # 2 p. 350 - 357

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26150-06-1 structure

26150-06-1

Literature: ISIS INNOVATION LIMITED Patent: US2012/178913 A1, 2012 ;

~24%

26150-06-1 structure

26150-06-1

Literature: Petersen, Svea; Alonso, Jose Maria; Specht, Alexandre; Duodu, Portia; Goeldner, Maurice; Del Campo, Aranzazu Angewandte Chemie - International Edition, 2008 , vol. 47, # 17 p. 3192 - 3195

~50%

26150-06-1 structure

26150-06-1

Literature: Breed; Ramsden; Brown Canadian Journal of Chemistry, 2001 , vol. 79, # 5-6 p. 1049 - 1057

~39%

26150-06-1 structure

26150-06-1

Literature: Ali-Adib, Ziad; Bomben, Andrea; Davis, Frank; Hodge, Philip; Tundo, Pietro; Valli, Ludovico Journal of Materials Chemistry, 1996 , vol. 6, # 1 art. no. 5/02127H, p. 15 - 22

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26150-06-1 structure

26150-06-1

Literature: Riemschneider; Koetzsch Monatshefte fuer Chemie, 1959 , vol. 90, p. 787,788,790