128660-97-9

128660-97-9 structure

Name: THP-PEG4-OH
Chemical Name: 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethanol
CAS Number: 128660-97-9
Molecular Formula: C₁₃H₂₆O₆
Molecular Weight: 278.342
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-06-25 07:54:59
Modify Date: 2024-01-02 23:48:22
THP-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethanol
Synonyms	Ethanol, 2-[2-[2-[2-[(tetrahydro-2H-pyran-2-yl)oxy]ethoxy]ethoxy]ethoxy]- 2-(2-{2-[2-(Tetrahydro-2H-pyran-2-yloxy)ethoxy]ethoxy}ethoxy)ethanol

Description	THP-PEG4-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.