2378261-80-2
2378261-80-2 structure
- Name: THP-PEG4-Pyrrolidine(N-Boc)-CH2OH
- Chemical Name: THP-PEG4-Pyrrolidine(N-Boc)-CH2OH
- CAS Number: 2378261-80-2
- Molecular Formula: C23H43NO9
- Molecular Weight: 477.59
- Catalog: Signaling Pathways PROTAC PROTAC Linker
- Create Date: 2020-04-12 12:20:04
- Modify Date: 2024-01-31 12:01:26
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THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1].
| Name | THP-PEG4-Pyrrolidine(N-Boc)-CH2OH |
|---|
| Description | THP-PEG4-Pyrrolidine(N-Boc)-CH2OH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523)[1]. |
|---|---|
| Related Catalog | |
| Target |
PEGs |
| In Vitro | PROTAC K-Ras Degrader-1 is potent K-Ras degrader based PROTAC, exhibits ≥70% degradation efficacy in SW1573 cells[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. |
| References |
[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2. |
| Molecular Formula | C23H43NO9 |
|---|---|
| Molecular Weight | 477.59 |
| Storage condition | -20°C |