1423058-85-8
1423058-85-8 structure
- Name: BRD 9757
- Chemical Name: brd9757
- CAS Number: 1423058-85-8
- Molecular Formula: C6H9NO2
- Molecular Weight: 127.14100
- Catalog: Signaling Pathways Cell Cycle/DNA Damage HDAC
- Create Date: 2018-02-03 08:38:37
- Modify Date: 2024-01-09 14:06:15
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BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1].
| Name | brd9757 |
|---|
| Description | BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC50 of 30 nM. BRD9757 shows excellent selectivity toward HDAC6 versus the class I (>20-fold) and class II (>400-fold) HDACs[1]. |
|---|---|
| Related Catalog | |
| Target |
HDAC6:0.03 μM (IC50) HDAC1:0.638 μM (IC50) HDAC2:1.79 μM (IC50) HDAC3:0.694 μM (IC50) HDAC4:21.80 μM (IC50) HDAC5:18.32 μM (IC50) HDAC7:12.61 μM (IC50) HDAC8:1.09 μM (IC50) HDAC9:>33.33 μM (IC50) |
| In Vitro | BRD9757（化合物 14）对抗 HDAC1、HDAC2、HDAC3、HDAC4、HDAC5、HDAC7、HDAC8 和 HDAC9，IC50 值分别为 0.638 μM、1.79 μM、0.694 μM、21.80 μM、18.32 μM、12.61 μM、1.09 μM 和 >33.33 μM[1]。 BRD9757（化合物 14；10-30 μM；24 小时）选择性地增加 Ac-tubulin 的水平，而不增加组蛋白乙酰化[1]。 Western Blot Analysis[1] Cell Line: HeLa cells Concentration: 10 μM and 30 μM Incubation Time: for 24 h Result: Increased the level of Ac-tubulin. |
| References |
| Molecular Formula | C6H9NO2 |
|---|---|
| Molecular Weight | 127.14100 |
| Exact Mass | 127.06300 |
| PSA | 49.33000 |
| LogP | 0.99300 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H319-H412 |
| Precautionary Statements | P273-P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |