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58822-25-6

58822-25-6 structure
58822-25-6 structure
  • Name: Leu-Enkephalin
  • Chemical Name: [leu5]-enkephalin
  • CAS Number: 58822-25-6
  • Molecular Formula: C28H37N5O7
  • Molecular Weight: 555.62300
  • Catalog: Biochemical Common amino acids and protein drugs
  • Create Date: 2018-05-29 08:00:00
  • Modify Date: 2024-01-03 16:40:15
  • [Leu5]-Enkephalin is a pentapeptides with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

Name [leu5]-enkephalin
Synonyms LEU-ENKEPHALIN
H-TyrGlyGlyPheLeu-OH
EINECS 261-457-1
L-TYR-GLY-GLY-PHE-LEU
SGS 518 oxalate
LEUCINE-ENKEPHALIN
Leu-Enkelphalin
L-leucine enkephalin
enkephalin,leucine
MFCD00076406
ENKEPHALIN L
TYR-GLY-GLY-PHE-LEU
YGGFL
H2N-Tyr-Gly-Gly-Phe-Leu-COOH
Description [Leu5]-Enkephalin is a pentapeptides with morphine like properties. [Leu5]-Enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.
Related Catalog
Target

Opioid receptors[1]

In Vitro Enkephalins (met- , leu-enkephalin, and enkephalin 8) and dynorphins are two classes of opioid peptides found in the spinal dorsal horn. Mu, delta, and kappa are three major subtypes of opioid receptors. Enkephalins are putative endogenous ligands for delta opioid receptors, and dynorphins are endogenous ligands for the kappa opioid receptors. Three receptor types resembling the vertebrate δ- and κ-type opioid receptors have been characterized pharmacologically in nervous tissues (e.g. Ki=18.9 nM for Leu-enkephalin) and localized by autoradiography at CHH terminals in the SG of C. maenas[1].Leucine-enkephalin is a pentapeptides with morphine like properties, naturally present in mammalian brain[2].
References

[1]. Leu-enkephalin is a five amino acid endogenous peptide that acts as an agonist at opioid receptors.

[2]. Meunier JC, et al. Binding of Leu5-enkephalin and Met5-enkephalin to a particulate fraction from rat cerebrum. FEBS Lett. 1977 May 15;77(2):209-13.

Density 1.274 g/cm3
Boiling Point 998.8ºC at 760 mmHg
Molecular Formula C28H37N5O7
Molecular Weight 555.62300
Flash Point 557.8ºC
Exact Mass 555.26900
PSA 199.95000
LogP 2.10130
Index of Refraction 1.586
Storage condition −20°C
Water Solubility Soluble in water (1 mg/ml ).
Safety Phrases S22-S24/25
WGK Germany 3