796073-70-6

796073-70-6 structure

Name: DM3-SMe
Chemical Name: N2'-deacetyl-N2'-[4-(R,S)-(methyldithio)-1-oxopentyl]maytansine
CAS Number: 796073-70-6
Molecular Formula: C₃₈H₅₄ClN₃O₁₀S₂
Molecular Weight: 812.43200
Catalog: Signaling Pathways Cell Cycle/DNA Damage Microtubule/Tubulin
Create Date: 2018-03-23 07:25:57
Modify Date: 2024-01-03 16:09:32
DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

Name	N2'-deacetyl-N2'-[4-(R,S)-(methyldithio)-1-oxopentyl]maytansine

Description	DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	Maytansinoids
References	[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.