DM3-SMe

Modify Date: 2024-01-03 16:09:32

DM3-SMe structure	Common Name	DM3-SMe
	CAS Number	796073-70-6	Molecular Weight	812.43200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₈H₅₄ClN₃O₁₀S₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DM3-SMe

DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].

Name	N2'-deacetyl-N2'-[4-(R,S)-(methyldithio)-1-oxopentyl]maytansine

Description	DM3-SMe is a maytansine derivative and a tubulin inhibitor, and is a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM3-SMe shows highly cytotoxic activity in vitro with an IC50 of 0.0011 nM[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Microtubule/Tubulin Signaling Pathways >> Cytoskeleton >> Microtubule/Tubulin
Target	Maytansinoids
References	[1]. Chen H, et al. Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy. Molecules. 2017 Aug 1;22(8). [2]. Yuliang Zhaoet al. Biomedical Nanomaterials. 2016-‎Science.

Molecular Formula	C₃₈H₅₄ClN₃O₁₀S₂
Molecular Weight	812.43200
Exact Mass	811.29400
PSA	207.07000
LogP	6.08820

DM3-SMe

Use of DM3-SMe

Names

DM3-SMe Biological Activity

Chemical & Physical Properties