DM4-SMe
Modify Date: 2024-01-14 17:02:47
DM4-SMe structure
|
Common Name | DM4-SMe | ||
|---|---|---|---|---|
| CAS Number | 796073-68-2 | Molecular Weight | 826.45900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C39H56ClN3O10S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DM4-SMeDM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2]. |
| Name | N2'-deacetyl-N2'-[4-methyl-4-(methyldithio)-1-oxopentyl]maytansine |
|---|
| Description | DM4-SMe is a metabolite of antibody-maytansin conjugates (AMCs) and a tubulin inhibitor, and also a cytotoxic moiety of antibody-drug conjugates (ADCs), which can be linked to antibody through disulfide bond or stable thioether bond. DM4-SMe inhibits KB cells with an IC50 of 0.026 nM[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Maytansinoids |
| References |
| Molecular Formula | C39H56ClN3O10S2 |
|---|---|
| Molecular Weight | 826.45900 |
| Exact Mass | 825.31000 |
| PSA | 207.07000 |
| LogP | 6.47830 |