799840-96-3

799840-96-3 structure

Name: Maytansinoid dM4
Chemical Name: Maytansinoid dM4
CAS Number: 799840-96-3
Molecular Formula: C₃₉H₅₆ClN₃O₁₀S
Molecular Weight: 794.394
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Cytotoxin
Create Date: 2019-01-07 15:51:07
Modify Date: 2024-01-19 11:44:41
Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2].

Name	Maytansinoid dM4
Synonyms	MFCD28144633

Description	Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
Target	Maytansinoids
In Vitro	Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus. Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin[1].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [2]. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.