Maytansinoid dM4

Modify Date: 2024-01-19 11:44:41

Maytansinoid dM4 structure	Common Name	Maytansinoid dM4
	CAS Number	799840-96-3	Molecular Weight	794.394
	Density	1.3±0.1 g/cm3	Boiling Point	940.2±65.0 °C at 760 mmHg
	Molecular Formula	C₃₉H₅₆ClN₃O₁₀S	Melting Point	N/A
	MSDS	N/A	Flash Point	522.4±34.3 °C

Use of Maytansinoid dM4

Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2].

Name	Maytansinoid dM4
Synonym	More Synonyms

Description	Maytansinoid DM4 is a thiol-containing maytansine derivative with highly potent cytotoxicity. Maytansinoid DM4 can be used as a cytotoxic moiety of ADC[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Cytotoxin
Target	Maytansinoids
In Vitro	Maytansine is a natural benzoansamacrolide product isolated from the bark of the African shrub Maytenus ovatus. Maytansine binds to the same site on tubulin as the vinca alkaloids, with similar in vitro inhibition constants, but is a more-potent cytotoxin[1].
References	[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. [2]. Zhao RY, et al. Synthesis and evaluation of hydrophilic linkers for antibody-maytansinoid conjugates. J Med Chem. 2011 May 26;54(10):3606-23.

Density	1.3±0.1 g/cm3
Boiling Point	940.2±65.0 °C at 760 mmHg
Molecular Formula	C₃₉H₅₆ClN₃O₁₀S
Molecular Weight	794.394
Flash Point	522.4±34.3 °C
Exact Mass	793.337463
LogP	6.26
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.587

MFCD28144633

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Maytansinoid DM4
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Purity: 98.0%
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