Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Cyclapolin 9
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Purity: 98.0%
Stocking Period: 10 Day
Contact: Huang

ShangHai DC Chemicals Co.,Ltd
China
Product Name: Cyclapolin 9
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai

DC Chemicals Limited
China
Product Name: Cyclapolin 9
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

40533-25-3

40533-25-3 structure

40533-25-3 structure

Name: Cyclapolin 9
Chemical Name: Cyclapolin 9
CAS Number: 40533-25-3
Molecular Formula: C₉H₄F₃N₃O₄S
Molecular Weight: 307.20600
Catalog: Signaling Pathways Cell Cycle/DNA Damage Polo-like Kinase (PLK)
Create Date: 2017-10-01 10:52:37
Modify Date: 2024-01-09 13:09:28
Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2].

Name	Cyclapolin 9
Synonyms	5-methylpyridazinecarboxamide 4-oxide 5-methyl-pyrazin-2-carboxamide-4-oxide 2-carbamoyl-5-methylpyrazine 4-oxide Pyrazinecarboxamide,5-methyl-,4-oxide 7-nitro-3-oxy-5-trifluoromethyl-benzothiazole-2-carboxylic acid amide L-NMMA acetate 5-methyl-pyrazine-2-carboxamide-4-oxide 2-Carbamoyl-5-methylpyrazin-4-oxid 5-methyl-4-oxy-pyrazine-2-carboxylic acid amide 2-Carbamoyl-7-nitro-5-trifluormethyl-benzothiazole-N-oxide

Description	Cyclapolin 9 is a potent, selective and ATP-competitive polo-like kinase 1 (PLK1) inhibitor with an IC50 of 500 nM. Cyclapolin 9 is inactive against other kinases[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Polo-like Kinase (PLK)
Target	PLK1:500 nM (IC50)
In Vitro	Cyclapolin 9 (3 μM) reduces electric field stimulation (EFS)-induced contractions of prostate strips. The α1-adrenergic smooth muscle contraction in the human prostate can be inhibited by Cyclapolin 9[1].
References	[1]. Martin Hennenberg, et al. Inhibition of Prostate Smooth Muscle Contraction by Inhibitors of Polo-Like Kinases. Front Physiol. 2018 Jun 15;9:734. [2]. Campbell McInnes, et al. Inhibitors of Polo-like kinase reveal roles in spindle-pole maintenance. Nat Chem Biol. 2006 Nov;2(11):608-17.

Molecular Formula	C₉H₄F₃N₃O₄S
Molecular Weight	307.20600
Exact Mass	306.98700
PSA	142.61000
LogP	3.57920

HS Code	2934999090

34576-35-7 structure

34576-35-7

~%

40533-25-3 structure

40533-25-3

Literature: CYCLACEL LIMITED Patent: WO2004/67000 A1, 2004 ; Location in patent: Page/Page column 25-26 ; WO 2004/067000 A1

Precursor 1
34576-35-7
DownStream 0

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%