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40951-21-1

40951-21-1 structure
40951-21-1 structure
  • Name: (±)-2-Hydroxyglutaric acid
  • Chemical Name: 2-Hydroxyglutaric Acid Disodium Salt
  • CAS Number: 40951-21-1
  • Molecular Formula: C5H8O5
  • Molecular Weight: 148.114
  • Catalog: Signaling Pathways Epigenetics Histone Demethylase
  • Create Date: 2018-06-11 20:56:28
  • Modify Date: 2024-01-04 21:26:53
  • α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].
Name 2-Hydroxyglutaric Acid Disodium Salt
Synonyms hydroxyglutaric acid
Pentanedioic acid, 2-hydroxy-
2-Hydroxypentanedioic acid
2-hydroxyglutaric acid
DL-2-Hydroxyglutaric
(RS)-2-Hydroxypentanedioic acid disodium salt Disodium 2-hydroxyglutarate
2-Hydroxy-pentanedioic acid
Description α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid disodium is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].
Related Catalog
Target

Microbial Metabolite

Human Endogenous Metabolite

In Vitro Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium, respectively[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) disodium inhibits the activity of TET 5-methylcytosine hydroxylases[1]. Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) disodium increases HIF-1α and decreases endostatin[1].
References

[1]. Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.  

Density 1.5±0.1 g/cm3
Boiling Point 394.2±27.0 °C at 760 mmHg
Melting Point >290ºC (dec.)
Molecular Formula C5H8O5
Molecular Weight 148.114
Flash Point 206.4±20.2 °C
Exact Mass 148.037170
PSA 94.83000
LogP -1.45
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.520

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MA3751000
CHEMICAL NAME :
Glutaric acid, 2-hydroxy-, disodium salt, L-alpha-
CAS REGISTRY NUMBER :
40951-21-1
LAST UPDATED :
199012
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C5-H6-O5.Na2
MOLECULAR WEIGHT :
192.09
WISWESSER LINE NOTATION :
OVYQ2VO &-NA- 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
RPTOAN Russian Pharmacology and Toxicology (English Translation). Translation of FATOAO. (Euromed Pub., 33, Woodlands Rd., Surbiton, Surrey, UK) V.30- 1967- Volume(issue)/page/year: 36,61,1973
Precursor  1

DownStream  0


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