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2889-31-8

2889-31-8 structure
2889-31-8 structure
  • Name: α-Hydroxyglutaric acid
  • Chemical Name: 2-hydroxyglutaric acid
  • CAS Number: 2889-31-8
  • Molecular Formula: C5H6O5--
  • Molecular Weight: 146.09800
  • Catalog: Signaling Pathways Epigenetics Histone Demethylase
  • Create Date: 2016-08-10 23:25:05
  • Modify Date: 2024-01-02 18:56:15
  • α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].

Name 2-hydroxyglutaric acid
Synonyms 2-hydroxyglutarate
Description α-Hydroxyglutaric acid (2-Hydroxyglutarate) is an α-hydroxy acid form of glutaric acid. α-Hydroxyglutaric acid is a competitive inhibitor of multiple α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methlycytosine (5mC) hydroxylases[1].
Related Catalog
In Vitro Isocitrate Dehydrogenase 1 (IDH1) and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of activities in the production of α-ketoglutarate (α-KG) and α-Hydroxyglutaric acid (2-Hydroxyglutarate), respectively[1]. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of multiple histone demethylases. α-Hydroxyglutaric acid occupies the same space as α-KG does in the active site of histone demethylases. α-Hydroxyglutaric acid (2-Hydroxyglutarate) inhibits the activity of TET 5-methylcytosine hydroxylases[1]. Treatment of U-87MG cells with α-Hydroxyglutaric acid (2-Hydroxyglutarate; 10-50 mM) increases HIF-1α and decreases endostatin[1].
References

[1]. Wei Xu, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases. Cancer Cell. 2011 Jan 18;19(1):17-30.

Molecular Formula C5H6O5--
Molecular Weight 146.09800
Exact Mass 146.02200
PSA 100.49000