63512-50-5

63512-50-5 structure

Name: L-2-Hydroxyglutaric acid disodium
Chemical Name: L-α-Hydroxyglutaric acid disodium salt
CAS Number: 63512-50-5
Molecular Formula: C₅H₆Na₂O₅
Molecular Weight: 192.078
Catalog: analytical chemistry food safety Fatty acid, fatty acid methyl ester
Create Date: 2018-07-04 22:22:42
Modify Date: 2024-01-05 16:18:19
L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].

Name	L-α-Hydroxyglutaric acid disodium salt
Synonyms	Pentanedioic acid, 2-hydroxy-, sodium salt (1:2) (2S)-2-Hydroxyglutaric Acid Disodium Salt Disodium 2-hydroxypentanedioate

Description	L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Demethylase
In Vitro	L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1].
References	[1]. Shim EH, et al. L-2-Hydroxyglutarate: an epigenetic modifier and putative oncometabolite in renal cancer. Cancer Discov. 2014 Nov;4(11):1290-8. [2]. da Silva CG, et al. L-2-hydroxyglutaric acid inhibits mitochondrial creatine kinase activity from cerebellum of developing rats. Int J Dev Neurosci. 2003 Jun;21(4):217-24.

RIDADR	NONH for all modes of transport