L-2-Hydroxyglutaric acid disodium
L-2-Hydroxyglutaric acid disodium structure
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Common Name | L-2-Hydroxyglutaric acid disodium | ||
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| CAS Number | 63512-50-5 | Molecular Weight | 192.078 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C5H6Na2O5 | Melting Point | >300ºC | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of L-2-Hydroxyglutaric acid disodiumL-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2]. |
| Name | L-α-Hydroxyglutaric acid disodium salt |
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| Synonym | More Synonyms |
| Description | L-2-Hydroxyglutaric acid disodium is an epigenetic modifier and putative oncometabolite in renal cancer. L-2-Hydroxyglutaric acid disodium can inhibit histone demethylases and hence promote histone methylation[1]. L-2-Hydroxyglutaric acid inhibits mitochondrial creatine kinase (Mi-CK) activity with Km and Ki of 2.52 mM and 11.13 mM, respectively[2]. |
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| Related Catalog | |
| In Vitro | L-2-Hydroxyglutaric acid is potent at inhibiting 2-oxoglutarate (2-OG) dependent dioxygenases (2OGDs) including the Ten Eleven Translocation (TET) enzymes[1]. |
| References |
| Melting Point | >300ºC |
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| Molecular Formula | C5H6Na2O5 |
| Molecular Weight | 192.078 |
| Exact Mass | 192.001068 |
| PSA | 100.49000 |
| Storage condition | −20°C |
| RIDADR | NONH for all modes of transport |
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Validation of a hypoxia-inducible factor-1 alpha specimen collection procedure and quantitative enzyme-linked immunosorbent assay in solid tumor tissues.
Anal. Biochem. 459 , 1-11, (2014) Hypoxia-inducible factor-1 alpha (HIF-1α) is an important marker of hypoxia in human tumors and has been implicated in tumor progression. Drugs targeting HIF-1α are being developed, but the ability to... |
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Prognostic significance of 2-hydroxyglutarate levels in acute myeloid leukemia in China.
Proc. Natl. Acad. Sci. U. S. A. 110(42) , 17017-22, (2013) The 2-hydroxyglutarate (2-HG) has been reported to result from mutations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) genes and to function as an "oncometabolite." To evaluate the clinical sign... |
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Serum 2-hydroxyglutarate production in IDH1- and IDH2-mutated de novo acute myeloid leukemia: a study by the Acute Leukemia French Association group.
J. Clin. Oncol. 32(4) , 297-305, (2014) Mutated isocitrate dehydrogenases (IDHs) 1 and 2 produce high levels of 2-hydroxyglutarate (2-HG). We investigated whether, in acute myeloid leukemia (AML), serum 2-HG would predict the presence of ID... |
| Pentanedioic acid, 2-hydroxy-, sodium salt (1:2) |
| (2S)-2-Hydroxyglutaric Acid Disodium Salt |
| Disodium 2-hydroxypentanedioate |