127457-63-0

127457-63-0 structure

Name: Benzyl-PEG3-acid
Chemical Name: 3-[2-(2-benzyloxyethoxy)ethoxy]propanoic acid
CAS Number: 127457-63-0
Molecular Formula: C₁₄H₂₀O₅
Molecular Weight: 268.30600
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2018-05-02 19:46:03
Modify Date: 2024-01-09 08:39:10
Benzyl-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	3-[2-(2-benzyloxyethoxy)ethoxy]propanoic acid
Synonyms	3-[2-(2-Benzyloxy-ethoxy)-ethoxy]-propionic acid

Description	Benzyl-PEG3-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562