1609960-31-7

1609960-31-7 structure

Name: TH 588
Chemical Name: N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine
CAS Number: 1609960-31-7
Molecular Formula: C₁₃H₁₂Cl₂N₄
Molecular Weight: 295.167
Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
Create Date: 2018-02-06 20:23:18
Modify Date: 2024-01-01 18:55:40
TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.IC50 value: 5 nM [1]Target: MTH1 inhibitorTH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts.

Name	N4-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine
Synonyms	2,4-Pyrimidinediamine, N-cyclopropyl-6-(2,3-dichlorophenyl)- N-Cyclopropyl-6-(2,3-dichlorophenyl)-2,4-pyrimidinediamine TH588

Description	TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1(IC50= 5 nM) in cells.IC50 value: 5 nM [1]Target: MTH1 inhibitorTH588 is highly selective towards MTH1, with no relevant inhibition of other members of the nudix protein family or a panel of 87 enzymes, GPCRs, kinases, ion channels and transporter. TH588 has been shown to selectively kill a variety of cancer cell lines and with in vivo activity shown for TH588 in SW480 colorectal and MCF7 breast tumour xenografts.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Research Areas >> Cancer
References	[1]. Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508(7495):215-21.