1831167-98-6
1831167-98-6 structure
- Name: DDP-38003 dihydrochloride
- Chemical Name: DDP-38003 dihydrochloride
- CAS Number: 1831167-98-6
- Molecular Formula: C21H28Cl2N4O
- Molecular Weight: 423.379
- Catalog: Signaling Pathways Epigenetics Histone Demethylase
- Create Date: 2018-03-26 23:28:24
- Modify Date: 2024-01-08 09:27:11
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DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM.
| Name | DDP-38003 dihydrochloride |
|---|---|
| Synonyms |
Benzamide, N-[4-[(1S,2R)-2-aminocyclopropyl]phenyl]-4-(4-methyl-1-piperazinyl)-, hydrochloride (1:2)
N-{4-[(1S,2R)-2-Aminocyclopropyl]phenyl}-4-(4-methyl-1-piperazinyl)benzamide dihydrochloride DDP-38003 (dihydrochloride) |
| Description | DDP-38003 dihydrochloride is an novel, orally available inhibitor of histone lysine-specific demethylase 1A (KDM1A/LSD1) with an IC50 of 84 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 84 nM (KDM1A/LSD1)[1] |
| In Vitro | DDP-38003 inhibits KDM1A with an IC50 of 84 nM. DDP-38003 is more active in reducing the colony forming ability and in inducing thedifferentiation of THP-1 cells compared to the 1R, 2S analogue[1]. |
| In Vivo | DDP-38003 exhibits in vivo efficacy after oral administration, determining a 62% increased survival in mouse leukemia models with evidence of KDM1A inhibition. The half life of DDP-38003 is 8 h. A significant dose dependent increase of mice survival is obtained by DDP-38003 treatment. The survival rate increases 35% and 62% at the dose of 11.25 and 22.50 mg/kg, respectively. DDP-38003 is a potential oral anticancer agent[1]. |
| Animal Admin | Mice: CD-1 mice is used in the study. DDP-38003 is dissolved (40% PEG 400 in a 5% glucose solution) and orally administered 3 days per week (Monday, Tuesday and Wednesday) for 3 weeks at the doses of 11.25 mg/kg and 22.5 mg/kg. The treatment started once blast cells are detected in the recipients' peripheral blood (10 days after cell injection). The survival of mice of the different experimental groups is analyzed and represented by a Kaplan-Meier survival plot[1]. |
| References |
| Molecular Formula | C21H28Cl2N4O |
|---|---|
| Molecular Weight | 423.379 |
| Exact Mass | 422.164032 |
| Storage condition | 2-8℃ |