1642297-01-5

1642297-01-5 structure

Name: GDC-0927
Chemical Name: GDC-0927
CAS Number: 1642297-01-5
Molecular Formula: C₂₈H₂₈FNO₄
Molecular Weight: 461.52
Catalog: Research Areas Cancer
Create Date: 2018-05-27 05:17:38
Modify Date: 2024-01-14 18:47:39
GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist.

Name	GDC-0927

Description	GDC-0927 (SRN-927) is a novel, potent, non-steroidal, orally bioavailable, selective estrogen receptor antagonist.
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
Target	Estrogen receptor[1]
In Vivo	GDC-0927 is a novel, potent, non-steroidal, orally bioavailable, selective ER antagonist/ER degrader (SERD) that induces tumor regression in estrogen receptor (ER)+breast cancer (BC) patient-derived xenograft models[1].
References	[1]. MN Dickler, et al. Abstract PD5-10: A first-in-human phase I study to evaluate the oral selective estrogen receptor degrader (SERD), GDC-0927, in postmenopausal women with estrogen receptor positive (ER+) HER2-negative metastatic breast cancer (BC). AACR; Cancer Res 2018;78(4 Suppl):Abstract nr PD5-10.