474432-66-1

474432-66-1 structure

Name: FAUC-365
Chemical Name: N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl}-1-benzothiophene-2-carboxamide
CAS Number: 474432-66-1
Molecular Formula: C₂₃H₂₅Cl₂N₃OS
Molecular Weight: 462.435
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-06-16 08:39:23
Modify Date: 2024-02-28 21:44:37
FAUC 365 is a highly dopamine D3 receptor-selective antagonist with Ki values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2short, and D2Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson's disease[1][2].

Name	N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl}-1-benzothiophene-2-carboxamide
Synonyms	N-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}-1-benzothiophene-2-carboxamide N-{4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl}-1-benzothiophene-2-carboxamide Benzo[b]thiophene-2-carboxamide, N-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butyl]-

Description	FAUC 365 is a highly dopamine D3 receptor-selective antagonist with Ki values of 0.5 nM, 340, 2600, and 3600 nM at D3, D4.4, D2short, and D2Long receptors, respectively. FAUC 365 can be used for the research of schizophrenia, and Parkinson's disease[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
References	[1]. Philip Seeman, et al. Dopamine D2 and D3 receptors in human putamen, caudate nucleus, and globus pallidus. Synapse. 2006 Sep 1;60(3):205-11. [2]. Carsten Hocke, et al. Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype. Bioorg Med Chem Lett. 2004 Aug 2;14(15):3963-6.