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  • DC Chemicals Limited
  • China
  • Product Name: ML-290
  • Price: $750.0/100mg $1500.0/250mg $3000.0/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

1482500-76-4

1482500-76-4 structure
1482500-76-4 structure
  • Name: ML-290
  • Chemical Name: ML290
  • CAS Number: 1482500-76-4
  • Molecular Formula: C24H21F3N2O5S
  • Molecular Weight: 506.49
  • Catalog: Research Areas Others
  • Create Date: 2018-07-21 11:12:20
  • Modify Date: 2024-01-01 21:15:33
  • ML-290 is a potent and orally active relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1].

Name ML290
Synonyms MFCD28118984
Benzamide, 2-(1-methylethoxy)-N-[2-[[[3-[(trifluoromethyl)sulfonyl]phenyl]amino]carbonyl]phenyl]-
2-Isopropoxy-N-[2-({3-[(trifluoromethyl)sulfonyl]phenyl}carbamoyl)phenyl]benzamide
ML290
ML-290
Description ML-290 is a potent and orally active relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1].
Related Catalog
Target

EC50: 94 nM (RXFP1)[1]

In Vitro ML-290 is a potent and orally active relaxin/insulin-like family peptide receptor (RXFP1) agonist and activator of anti-fibrotic genes, with an EC50 of 94 nM[1]. ML290 (5 μM) shows anti-fibrotic, relaxin-like gene expression at 24 and 72 h in activated human hepatic stellate cells[1].
References

[1]. Wilson KJ, et al. Optimization of the first small-molecule relaxin/insulin-like family peptide receptor (RXFP1) agonists: Activation results in an antifibrotic gene expression profile. Eur J Med Chem. 2018 Aug 5;156:79-92.

Density 1.4±0.1 g/cm3
Boiling Point 523.5±50.0 °C at 760 mmHg
Molecular Formula C24H21F3N2O5S
Molecular Weight 506.49
Flash Point 270.4±30.1 °C
Exact Mass 506.112335
LogP 5.00
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.590
Storage condition 2-8℃
RIDADR NONH for all modes of transport