1802661-73-9
1802661-73-9 structure
- Name: ONO-8590580
- Chemical Name: ONO-8590580
- CAS Number: 1802661-73-9
- Molecular Formula: C21H21FN6
- Molecular Weight: 376.43
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2019-01-20 03:58:06
- Modify Date: 2024-01-05 20:51:25
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ONO-8590580 is a GABAA α5 negative allosteric modulator.
| Name | ONO-8590580 |
|---|
| Description | ONO-8590580 is a GABAA α5 negative allosteric modulator. |
|---|---|
| Related Catalog | |
| Target |
GABAA α5[1]. |
| In Vivo | The effect of ONO-8590580 on the MK-801/scopolamine-induced cognitive deficit in the 8-arm radial maze test is investigated. Doses of MK-801 and scopolamine for this test are 0.075 mg/kg (i.p.) and 0.2 mg/kg (i.p.) respectively. ONO-8590580 (20 mg/kg, p.o.) significantly decreases the number of errors and total latency compared to the control. The present study in which ONO-8590580 but not donepezil significantly decreases the number of errors may suggest that ONO-8590580 could be more potent for the treatment of AD patients. The data showing that ONO-8590580 has not anxiogenic-like or proconvulsant effects are in agreement with the behavioral phenotype of α5-/- mice[1]. |
| Animal Admin | Rats[1] Male Sprague-Dawley rats are used. ONO-8590580 is orally administered 1 h before sacrifice. [3H]-Ro15-4513 (1.11 MBq/kg) is administered via the tail vein (1 mL/kg) 10 min before sacrifice. Rats (n=12 in each group) are given either vehicle, ONO-8590580 (20 mg/kg, p.o.), or as a positive control, the GABAA nonselective NAM FG-7142 (15 mg/kg, i.p.). After 1 h, rats are placed in the elevated plus maze for 5 min. Light intensity in the open arms is set at 20 lx. A video camera fitted with a polarizing lens is mounted above the maze, connected to a tracking and analyse system[1]. Mice[1] Mice (n=8 in each group) are intraperitoneally administered with either vehicle, ONO-8590580 (10 mg/kg), or FG-7142 (10 mg/kg). After 30 min, the mice are infused with 15 mg/mL PTZ solution (infusion rate 0.2 mL/min), and the time taken to reveal clonic seizures is measured, and from this the dose administrated is calculated[1]. |
| References |
| Molecular Formula | C21H21FN6 |
|---|---|
| Molecular Weight | 376.43 |
| Storage condition | 2-8℃ |