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  • DC Chemicals Limited
  • China
  • Product Name: ONO-5334
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

868273-90-9

868273-90-9 structure
868273-90-9 structure
  • Name: ONO-5334
  • Chemical Name: N-[(1S)-3-{(2Z)-2-[(4R)-3,4-Dimethyl-1,3-thiazolidin-2-ylidene]hydrazino}-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl]cycloheptanecarboxamide
  • CAS Number: 868273-90-9
  • Molecular Formula: C21H34N4O4S
  • Molecular Weight: 438.584
  • Catalog: Signaling Pathways Metabolic Enzyme/Protease Cathepsin
  • Create Date: 2020-01-20 17:24:57
  • Modify Date: 2024-01-12 16:36:31
  • A potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively; shows less or no potentcy for human cathepsin S/L/B/C (Ki=0.83/1.7/32/2500 nM); inhibits human osteoclasts bone resorption in vitro at a concentration more than 100 fold lower than that of alendronate; reduces plasma calcium level increased by PTHrP in thyroparathyroidectomized rats, decreases serum and urine C-telopeptide of type I collagen level. Osteoporosis Phase 2 Discontinued

Name N-[(1S)-3-{(2Z)-2-[(4R)-3,4-Dimethyl-1,3-thiazolidin-2-ylidene]hydrazino}-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl]cycloheptanecarboxamide
Synonyms 2H-Pyran-4-propanoic acid, β-[(cycloheptylcarbonyl)amino]tetrahydro-α-oxo-, 2-[(2Z,4R)-3,4-dimethyl-2-thiazolidinylidene]hydrazide, (βS)-
N-[(1S)-3-{(2Z)-2-[(4R)-3,4-Dimethyl-1,3-thiazolidin-2-ylidene]hydrazino}-2,3-dioxo-1-(tetrahydro-2H-pyran-4-yl)propyl]cycloheptanecarboxamide
MFCD28139071
Description A potent, selective, orally active inhibitor of cathepsin K with Ki of 0.1 nM, 0.049 nM and 0.85 nM for human, rabbit and rat cathepsin K, respectively; shows less or no potentcy for human cathepsin S/L/B/C (Ki=0.83/1.7/32/2500 nM); inhibits human osteoclasts bone resorption in vitro at a concentration more than 100 fold lower than that of alendronate; reduces plasma calcium level increased by PTHrP in thyroparathyroidectomized rats, decreases serum and urine C-telopeptide of type I collagen level. Osteoporosis Phase 2 Discontinued
References References 1. Ochi Y, et al. Bone. 2011 Dec;49(6):1351-6. 2. Ochi Y, et al. Bone. 2014 Aug;65:1-8. doi: 10.1016/j.bone.2014.04.023. 3. Ochi Y, et al. J Bone Miner Metab. 2014 Nov;32(6):645-52. 4. Nagase S, et al. Br J Clin Pharmacol. 2012 Dec;74(6):959-70. View Related Products by Target Cathepsin Osteoporosis
Density 1.4±0.1 g/cm3
Molecular Formula C21H34N4O4S
Molecular Weight 438.584
Exact Mass 438.230072
LogP 1.34
Index of Refraction 1.644