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1351636-18-4

1351636-18-4 structure
1351636-18-4 structure
  • Name: ONO-4059
  • Chemical Name: tirabrutinib
  • CAS Number: 1351636-18-4
  • Molecular Formula: C25H22N6O3
  • Molecular Weight: 454.481
  • Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK Btk
  • Create Date: 2018-09-28 14:16:22
  • Modify Date: 2024-01-06 17:26:21
  • Tirabrutinib (ONO-4059) is a highly selective, orally bioavailable BTK inhibitor with an IC50 of 2.2 nM.

Name tirabrutinib
Synonyms tirabrutinib
MFCD28386296
8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3R)-1-(1-oxo-2-butyn-1-yl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-
UNII:LXG44NDL2T
6-Amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
ONO-BKT
ONO-4059
Density 1.4±0.1 g/cm3
Boiling Point 672.0±65.0 °C at 760 mmHg
Molecular Formula C25H22N6O3
Molecular Weight 454.481
Flash Point 360.2±34.3 °C
Exact Mass 454.175354
LogP 2.31
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.700