Name | 6-Amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)-8H-purin-8-one |
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Synonyms |
9-[(3S)-1-Acryloyl-3-piperidinyl]-6-amino-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one
8H-Purin-8-one, 6-amino-7,9-dihydro-9-[(3S)-1-(1-oxo-2-propen-1-yl)-3-piperidinyl]-7-(4-phenoxyphenyl)- ONO-4059 ONO4059 analog ONO-4059 (analog) |
Description | The product is the analog of ONO-4059, ONO-4059 is a highly potent and selective Btk inhibitor with an IC50 in the sub-nM range. IC50 value: sub-nM range [2]Target: Btkin vitro: ONO-4059 ( analog ) is a selective, once-daily, oral inhibitor of BTK, which has been shown to play a role in the survival and proliferation of malignant B-cells. ONO-4059 (analog) shows a favourable safety profile along with promising efficacy in this difficult-to-treat patient population. [1]in vivo: ONO-4059 (analog) has demonstrated anti-tumour activity in several pre-clinical models.[1] ONO-4059 (analog) potently and dose-dependently reverse clinical arthritis and prevented bone damage in the CIA model.[2] |
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Related Catalog | |
References |
Density | 1.4±0.1 g/cm3 |
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Boiling Point | 714.0±70.0 °C at 760 mmHg |
Molecular Formula | C25H24N6O3 |
Molecular Weight | 456.496 |
Flash Point | 385.6±35.7 °C |
Exact Mass | 456.190979 |
LogP | 1.82 |
Vapour Pressure | 0.0±2.3 mmHg at 25°C |
Index of Refraction | 1.677 |
Storage condition | -20℃ |
Hazard Codes | N |
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