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2113688-43-8

2113688-43-8 structure
2113688-43-8 structure
  • Name: SNIPER(AR)-51
  • Chemical Name: SNIPER(AR)-51
  • CAS Number: 2113688-43-8
  • Molecular Formula: C55H65N7O8S
  • Molecular Weight: 984.21
  • Catalog: Research Areas Cancer
  • Create Date: 2019-06-02 08:45:44
  • Modify Date: 2024-01-14 16:39:27
  • SNIPER(AR)-51 (AR-51), consists of a cIAP1 ligand and an androgen ligand, connected by a linker[1]. SNIPER(AR)-51 induces androgen receptor (AR) protein degradation[1].

Name SNIPER(AR)-51
Description SNIPER(AR)-51 (AR-51), consists of a cIAP1 ligand and an androgen ligand, connected by a linker[1]. SNIPER(AR)-51 induces androgen receptor (AR) protein degradation[1].
Related Catalog
In Vitro SNIPER(AR)-51 (3 μM; 24 hours) exhibits a pronounced effect on the cell morphology of VCaP cells to induce apoptosis[1]. SNIPER(AR)-51 (3 μM; 24 hours) induces caspase-3 activation and PARP cleavage in prostate cancer VCaP cells[1]. Apoptosis Analysis[1] Cell Line: Prostate cancer VCaP cells Concentration: 3 μM Incubation Time: 24 hours Result: Induced apoptosis. Western Blot Analysis[1] Cell Line: VCaP cells Concentration: 1 μM and 3 μM Incubation Time: 24 hours Result: Induced caspase-3 activation and PARP cleavage at 3 μM.
References

[1]. Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of AndrogenReceptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61(2):543-575.

Molecular Formula C55H65N7O8S
Molecular Weight 984.21