2249801-12-3

2249801-12-3 structure
2249801-12-3 structure
  • Name: MD2-TLR4-IN-1
  • Chemical Name: MD2-TLR4-IN-1
  • CAS Number: 2249801-12-3
  • Molecular Formula: C22H14Cl2N4O
  • Molecular Weight: 421.28
  • Catalog: Signaling Pathways Immunology/Inflammation Toll-like Receptor (TLR)
  • Create Date: 2019-08-03 18:17:59
  • Modify Date: 2024-01-12 15:57:01
  • MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].

Name MD2-TLR4-IN-1
Synonyms MFCD32067977
Description MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].
Related Catalog
Target

MD2-TLR4[1].

References

[1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.

Molecular Formula C22H14Cl2N4O
Molecular Weight 421.28
Hazard Codes Xi