2309172-48-1
2309172-48-1 structure
- Name: LDN-192960 hydrochloride
- Chemical Name: LDN-192960 hydrochloride
- CAS Number: 2309172-48-1
- Molecular Formula: C18H22Cl2N2O2S
- Molecular Weight: 401.35
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Haspin Kinase
- Create Date: 2019-10-12 15:32:23
- Modify Date: 2024-01-10 02:09:08
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LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1].
| Name | LDN-192960 hydrochloride |
|---|
| Description | LDN-192960 hydrochloride is an inhibitor of Haspin and Dual-specificity Tyrosine-regulated Kinase 2 (DYRK2) with IC50s of 10 nM and 48 nM, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
IC50: 10 nM (Haspin); 48 nM (DYRK2)[1] |
| In Vitro | LDN-192960 hydrochloride (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC50<1 μM), including CLK1 (IC50=0.21 μM), DYRK1A (IC50= 0.10 μM), DYRK2 (IC50=2 nM), DYRK3 (IC50=19 nM) and PIM1 (IC50=0.72 μM)[1]. |
| References |
| Molecular Formula | C18H22Cl2N2O2S |
|---|---|
| Molecular Weight | 401.35 |